Protein Purification
MilliporeSigma™ Calbiochem™ IκB Ubiquitination Inhibitor, GS143
A cell-permeable, selective inhibitor of E3 ligase complex SCFβTrCP1-mediated ubiquitination of phosphorylated IκBα (IC50 = 5.2 μM).
MilliporeSigma™ Calbiochem™ SIRT2 Inhibitor II, AK-1
The SIRT2 Inhibitor II, AK-1, also referenced under CAS 330461-64-8, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Carbonic Anhydrase IX/XII Inhibitor
The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ JNK Inhibitor II
JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC50 = 40 nM for JNK-1 & JNK-2 & 90 nM for JNK-3).
MilliporeSigma™ Calbiochem™ DNA-PK Inhibitor V
The DNA-PK Inhibitor V, also referenced under CAS 404009-46-7, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Psalmotoxin-1
A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nM) that can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b.
MilliporeSigma™ Calbiochem™ Photochromic TrpA1 Channel Activator, Optovin
A rhodanine-derived, reversible, photoactivated, TrpA1-selective channel activator.
MilliporeSigma™ Calbiochem™ TNF-α Antagonist III, R-7050
The TNF-α Antagonist III, R-7050, also referenced under CAS 303997-35-5, controls the biological activity of TNF-α.
MilliporeSigma™ Calbiochem™ MMP-2/MMP-9 Substrate I, Fluorogenic
A fluorogenic substrate for both the 72 kDa human fibroblast gelatinase (HFG; MMP-2) and the 92 kDa human neutrophil gelatinase (HNG; MMP-9).
MilliporeSigma™ Calbiochem™ Ezh2 Inhibitor II, EI1
A cell-permeable indolocarboxamide compound
MilliporeSigma™ Calbiochem™ 17-DMAG
A potent antitumor analog of 17-AAG that binds to the ATPase site of human Hsp90α with high affinity and displays excellent bioavailability and aqueous solubility.
MilliporeSigma™ Calbiochem™ CDC25 Phosphatase Inhibitor II, NSC 663284
The CDC25 Phosphatase Inhibitor II, NSC 663284, also referenced under CAS 383907-43-5, controls the biological activity of CDC25 Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Akt Inhibitor XII, Isozyme-Selective, Akti-2
The Akt Inhibitor XII, Isozyme-Selective, Akti-2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ AICA-Riboside, 5'-Phosphate
A 5'-phosphorylated analog of membrane permeable AICA-Riboside that mimics AMP and acts as an activator of AMPK (AMP-activated protein kinase).
MilliporeSigma™ Calbiochem™ JAK3 Inhibitor VI
The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.